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Guido Núñez-Mujica

 

Supporters Of The Venezuelan Govt. Assault Opposition Members

One of the worst aspects of this so called Bolivarian Revolution is the way in that opposition is silenced and abused by unofficial groups that support the government. The Venezuelan govt claims that there is no violation of rights and that we have complete liberty, but it fails to prevent that this kind of groups threaten and assault others. All the explanations and talk of the Venezuelan govt is irrelevant when these shock groups show up to crush dissent and keep people afraid from speaking their minds. 

Lately, we have been having a lot of blackouts. We already had had  a lot of blackouts in 2009 and 2010, while the govt, too busy forbidding videogames and trying to censor the Internet, dragged its feet to fix the infrastructure (The utilities company used to be private, it was absorbed by the govt., who has been unable to keep it running) and we are having blackouts again. A group of people from Primero Justicia, an opposition party (and not my favorite one) started to protest and issued an statement to the media about the gross negligence of the govt., demading solution to these problems, however, their demonstration was interrupted by thugs supporting the govt. who assaulted several people there.

 

Think about it: Here is a group demanding that a government who claims to care about the poor and to be building a better country actually walk the talk and solve the problems it has created, problems that did not exist before, and these thugs are punching them because they don't agree with their politics. Whatever you think about the role of the state in the economy, this is simply beyond the pale, but it is routine here. Every now and then it happens, nobody gets prosecuted, even if they are caught in video. Next time you hear somebody talking about how wonderful and respectful of civil liberties is the Venezuelan govt, show them this clip. This kind of thing has happened many times before, but seldom in front of cameras like this. Usually the claims about this kind of assault are dismissed as right-wing fabrications, and with the hectic news cycle of this country, with the thousands of dead people because of crime, the blackouts, and constant callousness of our politicians, events like this are soon forgotten. I am writing this post because I want to document what is going on, and this is a great example. Even if I am really busy these days, it is my duty to speak when I can, tell others what's going on here, the truth behind the cynical claims of respecting liberties that my govt constantly makes.

Filed under  //   Guido Núñez-Mujica   Political VIolence   Venezuela  

More Visions of Our BioFuture

Will the same happen with GMO crops?

 

As I have said before, low cost biotechnology is just the latest development on a story that is 9000 years old. It's the story of our conscious relationship to nature, how we have tweaked, selected and bred animals and plants to serve our needs and please our tongues, noses and eyes. What we intend to do is just simply to bring the amateur once again to a pivotal role in solving his or her problems, to reduce the cost of the infrastructure needed for this kind of research and agricultural development so it is affordable by farmers and regular people, not only for universities and the industry.

Others have exposed this vision much better than my broken English allows me, so I selected a few articles, interviews and ideas to show how different, and richer, healthier, could be our world in the future, if we can develop the tools for cheap biotechnology and the people uses them.

The first is an article from Freeman Dyson, one of the greatest physicists alive, and a man with an incredible imagination. The article, Our Biotech Future, describes a future where biotechnology is decentralized and common, where modifying not genes, but whole genomes, is a form of art. If you feel offended, or grossed out, I just invite you to check a dog show when you can. These furry, playful and cute creatures are very different from their ancestors, due to our selective pressure, yet they are beloved by many and familiar to billions.

I can't resist to quote Dyson:

I see a close analogy between John von Neumann’s blinkered vision of computers as large centralized facilities and the public perception of genetic engineering today as an activity of large pharmaceutical and agribusiness corporations such as Monsanto. The public distrusts Monsanto because Monsanto likes to put genes for poisonous pesticides into food crops, just as we distrusted von Neumann because he liked to use his computer for designing hydrogen bombs secretly at midnight. It is likely that genetic engineering will remain unpopular and controversial so long as it remains a centralized activity in the hands of large corporations.

(...)

Domesticated biotechnology, once it gets into the hands of housewives and children, will give us an explosion of diversity of new living creatures, rather than the monoculture crops that the big corporations prefer. New lineages will proliferate to replace those that monoculture farming and deforestation have destroyed. Designing genomes will be a personal thing, a new art form as creative as painting or sculpture.

Whether you agree or not with Dyson, the essay is interesting, thought provoking and a real eye opener on some of the possibilities of low cost biotechnology.

Another piece that I would like to show you another article, not one talking about a hypothetical future, but one talking about what people are doing now concerning DIY Biology, a close relative of low cost biotechnology. This is an interview with one of the co-founders of a communal space for amateur biologists and startups, Biocurious, Joseph Jackson (Disclaimer: Joseph is also the co-founder of LavaAmp, my own bio-startup). Joseph speaks about the success of Biocurious to raise funds for a lab., and what they expect to do in the mid term:

In sum, BioCurious aims to democratize, demystify, and domesticate biotechnology by bringing together academia, industry, and members of the public to collide and collaborate in novel ways in a non-institutional setting.  Our space fills the void in the niches left unexplored by University or Corporate labs.  By getting these different sectors to interact, we can beneficially disrupt the way life sciences research is done.

Even the most far fetched discoveries might prove useful for people in trouble. A case of this might well be arsenic-contaminated water from underground wells and the newly announced arsenic-tolerant microbes. If we can learn the biochemical tricks that enable these bacteria to thrive in this environment, maybe we can incorporate them to local bacteria already living in the wells, so they capture the arsenic in a way harmless to us. Since bacteria are self replicant, this could be a very economic and scalable solution, as suggested by the DIY Biologist Cathal Garvey and also by Vidyanand Nanjundiah, an evolutionary biologist from Bangalore.

It's easy to be skeptic about genetic engineering and synthetic biology ever being accepted, specially with all the hysteria surrounding GM foods, however, this is not a new situation. We get our nourishment from food, it is understandable that people are concerned about new additions to diet, and in the past, foods that we love and enjoy were accused of being poisonous, like the tomato, or even of being a creation of the devil and causing leprosy, like the potato. Eventually they were accepted as delicious food and now they are part of the diet, culture and traditions of many regions in Europe and around the world. I am confident that the same will happen eventually with GM foods grown locally, and with biotech solutions to sanitary and environmental problems. We cannot afford to ignore the power of these tools to make our lives better and be a part of the solution for many problems currently unsolved.

Filed under  //   Cathal Garvey   Freeman Dyson   Guido Núñez-Mujica   Jospeh Jackson   Potato   Tomato   agriculture   low cost biotechnology  

Why llamas are in the future of low cost biotech

Llama Overlooking Machu Picchu

The llamas, Lama glama, are Andean camelids that have been the domestic animal of several local cultures for thousands of years. They have been used for their wool, meat and ability to carry weight, however, they have been also somewhat popular in contemporary culture, probably due to their highly cuddly looks. However, llamas (and alpacas and vicuñas, their relatives) are called to have an important role in the development of low-cost biotechnology and mobile diagnostic tools.

Many modern diagnostic methods are based in antibodies, complex molecules that are in our blood and in the blood of mammals, birds, fishes and reptiles. The antibodies are able to detect a specific substance and bind to it, allowing us to know if a certain bacteria or virus is in a sample, or if a person or animal has been exposed to a disease, as antibodies are only produced after contact with a pathogen, or vaccination. The antibodies used to detect diseases are usually extracted from goats, mice or rabbits, among others, even if later they can be produced using cell cultures, their original source is a living animal, that in the case of mid-sized and big animals, is not killed during the blood extraction process.

One of the main problems of working with antibodies is that they are very fragile molecules. They need to be stored on the freezer and even an overnight exposure to room temperatures can destroy their specific binding properties, making them useless, as many careless biologists could tell you. However, the antibodies of the camelids are special, some of them are smaller than the antibodies of other mammals and more robust, being able to stand temperatures close to the boiling point of water and still preserve their affinity to their target. This would make possible the application of very precise and sensitive diagnostic methods outside the laboratory, on the field, for a faster response to outbreaks and less expensive, in situ, testing of cattle, crops and even people.

For these reasons, llama antibodies offer a great tool for research and diagnostic in South America, and many other places, they also open the door for creating new diagnostic techniques, unthinkable before, that allows us to get biotechnology out of the laboratory and take where it it is needed. I think that these antibodies are going to become a standard part of the toolbox for low cost biotechnology and be useful for solving local problems at a low cost, without needing millions of dollars, but only ingenuity, a few chemical reagents, a clean workspace and some llamas.

Biotechnology has some new, cute furry friends.

I hope to launch some early testing of the possibilities of these antibodies early next year, as we are thinking of some very intriguing possibilities for new diagnostic methods, and we are about to get some llamas very soon.

And now, for something completely different, but still related to llamas and Spanish:


Filed under  //   Antibodies   Guido Núñez-Mujica   Llamas   Venezuela   low cost biotechnology